A systematic framework for predictive biomarkers in immune effector cell-associated neurotoxicity syndrome

A systematic framework for predictive biomarkers in immune effector cell-associated neurotoxicity syndrome

Blog Article

Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the management of several life-threatening malignancies, often achieving durable sustained responses.The number of patients treated with this new class of cell-based MENS T-SHIRTS therapy, along with the number of Food and Drug Association (FDA) approved indications, are growing significantly.Unfortunately Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) can often occur after treatment with CAR-T cells, and severe ICANS can be associated with significant morbidity and mortality.Current standard treatments are mainly steroids and supportive care, highlighting the need for early identification.

In the last several years, a range of predictive biomarkers have been proposed to distinguish patients Grill Cleaners at increased risk for developing ICANS.In this review, we discuss a systematic framework to organize potential predictive biomarkers that builds on our current understanding of ICANS.